Oleh Much. Khoiri
Ada yang tampak unik dan sangat menarik dalam launching buku dalam rangka kopdar 3 Rumah Virus Literasi (2024) di BBGP Provinsi Jawa Timur, 26-27 Oktober 2024. Apa gerangan itu?
Dari putaran vidio launching buku, pada urutan kedua setelah founder RVL, ada nama penulis Drs. H.M Dachlan S., sosok penulis tertua peserta launching—dalam kondisi berdiri, memegang bukunya berjudul “Sepuluh Kiat Jitu membentuk Keluarga Bahagia” (2024), bersampul biru cerah dengan foto diri dan rumah adat.
Puang Bapak memegang buku sambil berdiri tegak. Sumber gambar: panitia RVL 2024
Mengapa beliau termasuk penulis tertua di antara penulis yang ikut launching buku? Dari penelusuran saya, beliau sekarang ini berusia 94 tahun—bahkan bisa dua kali lipat usia sebagian peserta lain, bahkan tiga kali lipat usia Mas Kacong, peserta paling bontot.
Eit, meski beliau penulis tertua, semangatnya jangan ditanya. Fisik boleh tua, tetapi semangat tetap anak muda. Lihatlah, beliau berusaha berdiri tegak dengan memegang buku barunya, itu mengirimkan pesan kepada kita, bahwa beliau harus tampak gagah dan kuat di mata generasi muda. Semangat menulisnya juga luar biasa—buktinya? Buku yang dipegangnya bukti nyata tak terbantahkan!
Dari penelusuran dari berbagai sumber, beliau masih lancar membaca, berbicara, dan menulis—meski perlahan. Membaca telah mendarah daging pada beliau, yang dilakukannya semenjak muda. Pikirannya masih runtut, lancar, dan enak diikuti saat lewat rekaman vidio beliau mengupas buku saya “Kitab Kehidupan: Mimum Kopimu, Baca Dirimu, Temukan Fitrahmu, Hayati Hidup Baru” (2023).
Buku yang dipegangnya sengaja dipersembahkan untuk kegiatan launching buku pada kopdar 3 RVL. Maka, keikutsertaan beliau dalam kopdar secara daring adalah bukti kesungguhan beliau dalam bidang menulis—bahkan menulis di usia senja.
Yang paling istimewa dari beliau, sebagaimana tercermin dalam judul buku beliau tersebut, adalah bahwa beliau menulis dengan menunjukkan keteladanan. Apa yang ditulis adalah apa pengalaman yang telah teruji, lalu ditulis sebagai panduan keteladanan bagi keluarga Tompo Tikka serta masyarakat sekitarnya.
Puang Bapak yang berdiri gagah sambil memegang bukunya. Gambar: Dok keluarga
Jika Anda ingin belajar banyak tentang bagaimana menulis buku yang berbasis pengalaman pribadi dalam mendidik keluarga, maka bacalah buku beliau, atau mampirlah ke rumah beliau untuk membuktikan kebenarannya.
Itulah Puang Bapak—begitu beliau disapa—penulis tertua yang menulis dengan keteladanan, yang menulis buku untuk warisan dan wahana pendidikan bagi keluarga dan generasi penerus. Dalam bahasa Bugis, saya ingin tahu, sebutan apakah yang paling cocok untuk beliau?[]
*Much. Khoiri adalah nama pena Dr. Much. Koiri, M.Si, Dosen FBS Unesa, Founder RVL, Ketua Apebskid Komisariat Jatim, sponsor literasi, editor/penulis buku. Tulisan ini pendapat pribadi.
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within the sport of Olympic weightlifting. Those who complete within the sport will spend a big period of
time with this exercise, perfecting every facet of the lift.
Coaching method, energy, speed, and automaticity with the carry are
of paramount significance. If you’re going to compete in Olympic
weightlifting, this movement must be automatic. Do some of these high-rep exercises in weightlifting shoes and some in running shoes.
Once your knees, hips and elbows are locked out, thesnatch is full,
and you can return the bar to the ground. The second pull is where the vast majority of the
pressure isgenerated to accomplish the lift. Beginning above the knee, to
the explosivepull, that is when the bar is moved to an overhead position. Brilliance in snatch technique is dependent upon two verydifferent abilities.
First, the flexibility to raise the bar, and second the
skill todrop speedily beneath the bar and to stabilize it overhead.
Snatches use momentum to carry a barbell above your head
in a fluid movement. It’s a dynamic movement requiring a stable core and managed stability.
These high-rep workouts give the athlete some choices in how
he chooses to do the snatch. Here is the place we can get artistic and resolve on a pre-workout strategy
to get the work accomplished as fast as possible.
This technique requires both power and coordination, making it a difficult however effective motion for bettering general fitness and energy.
The snatch is a demanding but rewarding lift that builds power, coordination, and
strength. By incorporating particular drills, assistance exercises, and refined mechanics, athletes can maximize effectivity
and performance in the snatch. The snatch exercise presents many benefits, including improved strength and power, elevated mobility and adaptability, and
enhanced core stability. By exploring its varied variations
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overhead squat snatch you’ll have the ability to additional
refine your training to fulfill specific targets.
A break up snatch requires extra talent than just a power snatch but is less difficult for
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workouts. One downside to this motion is the necessity to reset
the toes after each rep. The size and subsequent depth of the break up will increase as
the load nears an athlete’s 1RM. The hang energy snatch is a simplified variation of
the grasp snatch and the total squat snatch. It is an Olympic weightlifting movement that is used to construct explosive energy
and power. It is a challenging train, but it can be mastered with focused practice and consistency.
The snatch raise is a fancy, full-body exercise that engages a number
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This raise includes hoisting a barbell from the ground to an overhead place in one fluid movement.
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with CrossFit and useful health packages. You can both carry the burden from the floor directly
to the grasp position and then pause before initiating the ability snatch (technically called a
section snatch or pause snatch). Or you can begin from
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barbell sits in your hip crease along with your arms absolutely prolonged
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It checks your energy, pace, flexibility, and coordination. Commit to constant apply,
mobility work, and structured programming, and you’ll see noticeable gains in your snatch approach, power, and general athletic performance.
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The hold snatch starts with the barbell held above the floor,
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This variation emphasizes the explosive pull and is beneficial for athletes specializing in energy development.
The hang energy snatch offers you much less time and distance to speed up
the bar. This can be utilized to improve pressure manufacturing by way of the second pull of the
motion and allow you to study to aggressively pull your self beneath the barbell.
From the Grasp Snatch to the Overhead Squat Snatch, there are a number of ways to range and problem your snatch method.
The triceps are essential when making an attempt heavy weight hundreds as they assist to lock out the
elbows after completing the complete pull, thus allowing for a successful lift without any kind or energy issues.
The biceps come into play previous to the final lockout, contracting concentrically
and maintaining the barbell close enough to generate maximum drive and enhance
success probabilities.
Discover where your palms are in relation to the knurl lines.
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time. From there, catch the barbell before returning again up into standing
position multi function fluid motion with out pausing between actions.
It is necessary to not lean too far forward when lunging down as this might
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and power.
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remains to be a “chicken and egg puzzle” the inhibition of one of
the two mechanisms can quench the activation of the opposite one, resulting in a decrease irritation and oxidative harm.
In view of these knowledge and to investigate the potential mechanism (s) underlying the anti-inflammatory properties of
SCA and SCB compounds, their potential results in inhibiting the exercise of COX,
a standard target for anti-inflammatory drugs, have been evaluated.
Interestingly, while SCA barely affected COX activity solely at the decrease focus tested (0.1
µM), SCB concentration-dependently (0.1–10 µM) inhibited COX exercise.
Antifungal198–202 and antiviral75,203–207 activities of FT inhibitors
and GGT-1 inhibitors have also been explored. The strategies of isolation to achieve the two scales of product are distinct,
however include extraction, precipitation, adsorption, chromatography, and crystallization. Despite their significant efficacy,
their many adverse effects restrict the utility
of corticosteroids. The route of administration for
corticosteroids depends women on steroids before and after; exodontia.info, many factors, primarily
being the dysfunction handled. The route could be parenteral, oral,
inhaled, topical, injected (intramuscular, intraarticular,
intralesional, intradermal, and so on.), and rectal.
The β subunits of FT and GGT-1 share 25% sequence identity
and have related general structures (Figure 3B) consisting of 14 and 13 α-helices, respectively.
Twelve α-helices of the β subunits are folded into an unusual α-α
barrel. Six parallel helices type the core of the barrel, and the other six kind
the surface of barrel, which is antiparallel to the inner core helices.
One end of the barrel is blocked by the C-terminal loop of the β subunits, and the opposite finish is open to the solvent and varieties a deep hydrophobic pocket within the center of the
barrel.
As noted in Part eight.7, this organic epoxidation mechanism is carefully analogous to the mechanism by which peroxyacids (RCO3H) react with alkenes to offer
epoxides within the laboratory. The drugs mexrenone (202) and canrenone (203) are steroids with a spironolactone in C-17 and are potent antagonists
of mineralocorticoids [95]. The dehydrogenation product (Δ1(2)-mexrenone,
207, 15%) was favored with Bacterium cyclooxidants in addition to Rhodococcus equi, Nocardia aurentia, and Comamonas testosteroni.
From the biotransformation of 203 using Corynespora cassiicola,
9α-hydroxycanrenone (208, 30%) was obtained, [96].
The conserved CRDs of DHHCs comprise many palmitoylated cysteine residues which are distinct from the catalytic cysteine.
These cysteines are located downstream of the DHHC domain and
form a novel motif, CCX(7–13)C(S/T).402 This motif is found in DHHC5, DHHC6, and DHHC8.
The operate of this modification on the DHHCs and its formation mechanism require additional research.
It could be a consequence of the auto-catalytic activity or the exercise of one
other DHHC on DHHC5, DHHC6, and DHHC8. Indeed, DHHC6 is a
downstream substrate for DHHC16 and the depalmitoylase APT2.472 When palmitoylated, however not when de-palmitoylated, DHHC6 has detectable exercise.
Diterpenoids are derived biosynthetically from geranylgeranyl diphosphate (GGPP),
which is itself biosynthesized by reaction of farnesyl diphosphate with isopentenyl diphosphate.
Show the construction of GGPP, and propose a mechanism for its biosynthesis from FPP and IPP.
Propose a mechanistic pathway for the biosynthesis of isoborneol.
A carbocation rearrangement is required at one point in the
scheme. Draw probably the most stable chair conformation of menthol, and label every substituent
as axial or equatorial.
However, the caspase-3 cleavage of NMT2 leads to the relocalization NMT2 from
the cytosol to the membrane fraction.236 The reasons for NMT-specific localization change during apoptosis require additional investigation.
Cerevisiae NMT in advanced with a non-hydrolyzable myristoyl-CoA analogue and
a peptide substrate (PDB ID 1IID). (B) Phe170 and Leu171 type
the oxyanion hole to stabilize the adverse charge developed on the
carbonyl oxygen of myristoyl-CoA throughout catalysis.
(C) The hydrophobic myristoyl group binds in a deep pocket in NMT.
(D) The peptide substrate recognition website of NMT, which explains the peptide
sequence specificity of NMT.
In 2006, this technique was used to profile international
S-palmitoylated proteins in yeast, which was
the first proteomics study of palmitoylation.447 Thirty-five
new palmitoylated proteins were recognized on this research.
Most Rab proteins have C-terminal CC or CXC motifs for digeranylgeranylation (Figure 7),
which is more hydrophobic. In phrases of membrane targeting, digeranylgeranylation appears only to target proteins
to endomembranes, as most Rab proteins are focused to specific intracellular membrane organelles, not the plasma membrane.
However, the consequences of digeranylgeranylation can differ from these of single
geranylgeranylation. Due To This Fact, the correct targeting
of Rab proteins is decided by prenylation; interactions with GEFs, effectors, and possibly other
proteins; and unfavorable costs on the plasma
membrane. The screening of a CaaL peptide library for FT substrates revealed that FT can farnesylate a selection of
CaaL peptides,64 which is opposite to the CaaX paradigm describing CaaL as the canonical GGT-1 substrate sequence.
Activation of the canonical NF-κB pathway depends on its capability to
translocate to the nucleus and bind with DNA
controlled by the inhibitor of κB (IκB). IκB
protein can bind NF-κB dimers to stop the activation of NF-κB.
The commonest member of IκB in mediating the activation of
the everyday NF-κB pathway is IκBα, which plays a central position in subsequent
transcription. In response to exterior stimulation, NF-κB-bound IκB protein undergoes particular phosphorylation,
ubiquitination, and proteasome-mediated proteolysis, permitting NF-κB to localize to the nucleus and bind to DNA and
transcribe for inflammatory genes together with IL-1a and IL-8.